Potassium diformate is an alternative to antibiotics
There are many opportunities for bacterial infection in the breeding production, because it is impossible to produce aseptic animals in the breeding environment, so it is inevitable to have disease. There are many substitutes for antibiotics, but due to the limitations of each product, such as the high cost of use, the complex methods of use, and the uncertain effect. At present, potassium diformate is a new type of feed additive which can replace antibiotics.
Potassium diformate has been approved by the European Union as a growth promoting agent for antibiotic substitutes. At the same time, the research on the synthesis and application of potassium diformate has been developed rapidly in China.
Potassium diformate is a kind of organic acid salt. It is a dimer which is associated by hydrogen bond between a molecule of formic acid and a molecule of potassium formate. The pure potassium diformate is white crystal or crystalline powder. Potassium diformate is tasteless, soluble in water, highly hygroscopic, stable in acid conditions, and decomposed into formic acid and potassium formate in neutral or alkaline conditions.
It is generally believed that the improvement of production performance after adding antibiotics to feed is related to the inhibition of subclinical infection. Therefore, the reason why potassium diformate can promote the growth of antibiotics is that it has a strong killing effect on pathogenic bacteria in the intestine. Its unique anti microbial function is based on the comprehensive effect of formic acid and formate. It is absorbed in the form of complete potassium diformate and passes through the acid stomach to the neutral and alkalescent hind intestinal tract, that is to say, it automatically decomposes into formic acid and formate. The non dissociated formic acid passes through the cell wall of the bacteria and makes the pH drop in the cell. When the pH in the cell is close to 7, organic acid dan enters the cell, destroying the enzyme function and nutrient delivery system in the cell, making the microorganism unable to reproduce, leading to death, and playing the function of bacteriostasis and sterilization: formate anion decomposes the protein of bacterial cell wall outside the cell wall, playing the role of sterilization and bacteriostasis.
Therefore, by adding potassium diformate to improve the biological safety, improve the breeding environment and feeding management, reduce the incidence of bacterial diseases, according to the loss caused by the disease.
Potassium diformate has been approved by the European Union as a growth promoting agent for antibiotic substitutes. At the same time, the research on the synthesis and application of potassium diformate has been developed rapidly in China.
Potassium diformate is a kind of organic acid salt. It is a dimer which is associated by hydrogen bond between a molecule of formic acid and a molecule of potassium formate. The pure potassium diformate is white crystal or crystalline powder. Potassium diformate is tasteless, soluble in water, highly hygroscopic, stable in acid conditions, and decomposed into formic acid and potassium formate in neutral or alkaline conditions.
It is generally believed that the improvement of production performance after adding antibiotics to feed is related to the inhibition of subclinical infection. Therefore, the reason why potassium diformate can promote the growth of antibiotics is that it has a strong killing effect on pathogenic bacteria in the intestine. Its unique anti microbial function is based on the comprehensive effect of formic acid and formate. It is absorbed in the form of complete potassium diformate and passes through the acid stomach to the neutral and alkalescent hind intestinal tract, that is to say, it automatically decomposes into formic acid and formate. The non dissociated formic acid passes through the cell wall of the bacteria and makes the pH drop in the cell. When the pH in the cell is close to 7, organic acid dan enters the cell, destroying the enzyme function and nutrient delivery system in the cell, making the microorganism unable to reproduce, leading to death, and playing the function of bacteriostasis and sterilization: formate anion decomposes the protein of bacterial cell wall outside the cell wall, playing the role of sterilization and bacteriostasis.
Therefore, by adding potassium diformate to improve the biological safety, improve the breeding environment and feeding management, reduce the incidence of bacterial diseases, according to the loss caused by the disease.
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