Do you need calcium formate as feed additive to implement a comprehensive "ban on resistance" in feed?

 The scale of the current aquaculture industry is increasing. If the leading enterprises can fully implement the anti-resistance action, the "no anti-resistance" production will be promoted faster and better. Replacement companies have been growing rapidly in continuous exploration, and a variety of replacement products have emerged in the market. The industry is increasingly calling for low-resistance, low-residue, safe and effective replacement products. Even without antibiotics, feed grade calcium formate can be used to help improve intestinal health and achieve the goal of healthy breeding.


At present, there are many types of antibiotic substitutes on the market, and the quality varies greatly. The effects of some products have not been fully certified, and the mechanism of action of some antibiotic substitutes is unclear. Various factors have added some uncertainty to breeding companies in choosing the right alternative substances. Feed grade calcium formate has very strong antibacterial, anti-virus, fungal and tumor cell activities, and is not toxic to animal cells, and its effect is comparable to antibiotics.


Behind that feed grade calcium formate is comparable to antibiotics, it is fundamentally different from antibiotics:

1. The source method is different. Antibiotics are secondary metabolites and enzymatic chemical reactions. The feed grade calcium formate comes from primary metabolites.

2. The structure is different. It is difficult for antibiotics to have a clear amino acid sequence, and there are amino acid derivatives or rare amino acids. The feed-grade calcium formate is a calcium organic acid synthesized from organic formic acid and calcium powder.

3. The body's immunity is different. Antibiotics kill bacteria, but basically have no effect on viruses, resulting in immunosuppression. The host defense protein (peptide) of feed grade calcium formate can improve non-specific immunity. It is produced by the innate immunity of organisms, used to fight foreign pathogens, can inhibit bacteria, inhibit viruses, fungi, protozoa, etc.

4. The mechanism of action is different. Some antibiotics inhibit DNA gyrase, some bind to the ribosomal 30S subunit to inhibit replication, and some bind to cell wall D-alanyl to inhibit bacterial synthesis. Feed grade calcium formate acts on the cell membrane of bacteria, destroying the permeability of the cell membrane, which is a devastating destruction and can quickly kill bacteria.


For more than 50 years, animal products have changed from luxury goods to cheap and high-quality daily food, and the contribution of feed drug additives is undeniable. But over time, the abuse of antibiotics has also caused various problems. Such as drug residues, bacterial resistance, environmental pollution, etc. Therefore, calcium formate is needed as feed additive that can replace antibiotics to achieve "anti-antibiotic prohibition" in feed and "anti-antibiotic restriction" in drugs.

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